How do I set up notifications for interface up/down & send them to different groups?

I am currently using Solar Winds Orion and I want to move to your PRTG Network Monitor program. We have a variety of alerts based on interface up/down changes, device up/down, threshold notifications, and some devices that are primarily down, but we are notified when they are up, and then go down again. There are different groups of people that need to be notified for different subsets of these. I have my equipment grouped logically, but the people that need to be notified cross these "boundaries". So as a higher level explanation - for interface changes, I get notified when all *significant* interfaces change. The server group is notified when the server interfaces change, the telecom guys get notfied on a change in their interface status. To further differentiate it, the telecom guys have servers too, and they only want alerts for their servers, not all servers. Sometimes the server interfaces are found accross my equipment group boundaries. And not all interfaces that are monitored need to have alerts generated when there is a change in status. I think if you can help me do this, then I can figure out the rest of the notifications that I have setup as well. I just can't wrap my mind around how to set all of this up and I've read the manual, but I'm missing a piece somewhere. Oh! And I am generating and receiving alerts based on up/down status of the equipment so the basics are there, it's just less typical stuff.

Thank you for your help!